Research Scientist

at University of Cape Town
Location Cape Town, Cape Town, South Africa
Date Posted
Category Healthcare
Work Hours Day
Salary Units MONTH
Currency ZAR


The Drug Discovery and Development Centre (H3D) is an interdisciplinary, soft-funded research unit at the University of Cape Town. H3D seeks a Research Scientist to provide scientific and technical support as part of an interdisciplinary translational research team discovering and developing innovative, lifesaving medicines. This Research Scientist will contribute significantly to the H3D enzymology platform and will be primarily responsible for profiling compounds in biochemical assays against drug targets of interest to support academic and H3D malaria drug discovery projects. The Research Scientist will work within H3D’s Biosciences group at the Institute of Infectious Diseases and Molecular Medicine (IDM).


  • BSc Honours degree in biochemistry/related discipline or equivalent (Lab Technician (National Technical Diploma or

equivalent) in scientific discipline such as biology, chemistry, or pharmacology and 2+ years relevant laboratory experience

would be deemed equivalent)

  • Demonstrated laboratory and analytical skills, with practical experience in standard laboratory techniques used in molecular

biology/enzymology/pharmacology/chemistry or related disciplines.

  • A good understanding of molecular biology principles including the principles underlying enzymology and protein chemistry.
  • Highly motivated scientist able to work in a team-focused setting
  • Meticulous with good time management and organisational skills
  • Good oral and written communication skills
  • Applicants must be South African citizens or permanent residents


Practical experience in the following is highly desirable:

  • Assay development/enzyme activity assays/enzyme inhibition studies
  • Setting up assays in 96/384/1536-well plates
  • Use of semi-automated/robotic liquid dispensers
  • Medium to high-throughput compound screening in biochemical or cell-based assays
  • Data analysis using GraphPad Prism or related software

Responsibilities will include, but are not limited to the following:

  • Profiling compounds against drug targets of interest in established routine medium to high-throughput biochemical assays
  • Analysing biochemical assay data
  • Troubleshooting assays and addressing issues with data generation as they arise
  • Routine laboratory activities to support the enzymology platform (e.g. ordering consumables, preparing reagent/buffer stock

solutions, maintaining laboratory equipment etc.)

  • Working with sample management to improve workflows


The annual remuneration package for 2021, including benefits is between R352 786 – R415 041.


To apply, please e-mail the below documents in a single pdf file to Ms. Elaine Rutherfoord-Jones at [email protected]

- UCT Application Form (download at

- A letter of motivation

- Curriculum Vitae (CV)

- A statement of your research interests